As I had worked a year for a private company investigating the non-invasive glucose detection using fs lasers, I am interested in the biomedical application of ultrafast lasers.
Stefan Witt, who used to work in Vrije University in Netherlands but recently joined JILA, presented his work of label free live (mouse) brain imaging back in Netherlands. They use third harmonic generation microscopy to perform brain imaging. IR pulses are used so that they can avoid the THG signal in the UV region. Also it has the advantage of minimal dispersion, better penetration depth and reduced excitation of endogenous molecules. As a result, they realized dye free 3D brain imaging of high resolution, manipulation of tissue with sub-cellular position (they can guide the patch clamping to the cell using the THG microscopy) and in vivo THG microscopy.
Marcos Dantus from Michigan state university also showed some interesting result of high resolution imaging of vegetable cells using a novel imaging mass spectrometry technique---Atmospheric pressure.
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